Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patientsArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] 바이오마커, [키워드] age analysed baseline biochemical parameter Biomarker CCL5 Clinical data Cohort COVID-19 COVID-19 patient creatinine D-dimer value Deceased ELISA Gender Gut hospitalised hospitalised COVID-19 patients intestinal permeability inverse correlation long-COVID longitudinal study marker microbial microbial translocation Mortality multivariable analyses obesity outcome patients Peru positive correlation Prothrombin time quantification RANTES sandwich ELISA serum sample severe COVID-19 infections Variation various inflammatory diseases zonulin. [DOI] 10.3389/fcimb.2022.1000291 PMC 바로가기
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patientsNF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험Article Published on 2022-08-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased [DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article
Bone Marrow-Derived Mesenchymal Stromal Cell Therapy in Severe COVID-19: Preliminary Results of a Phase I/II Clinical TrialClinical Trial Published on 2022-07-042022-10-04 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome adverse effect ARDS bone Bone marrow cells cellular cellular therapy clinical Cohort control patient control patients COVID-19 COVID-19 disease Critical D-dimer value Dexamethasone Efficacy Endocarditis evaluate extracorporeal membrane oxygenation group high mortality High-flow nasal oxygen Immune cell Immune-mediated induce Inflammation Inflammatory response intensive care intensive care unit (ICU) interval intravenous infusion invasive Invasive mechanical ventilation limit mechanical ventilation median mesenchymal stromal cells. MSC MSC-treated MSCs nasal no significant difference observation outcome oxygen Patient patients phase phenotype Randomized controlled trial Regulatory reported required requiring supplemental oxygen Result Safe SARS-CoV-2 severe COVID-19 significantly higher significantly lower Statistical tests stimulate stroke stromal cell survival syndrome therapy tissue repair treated Trial [DOI] 10.3389/fimmu.2022.932360 PMC 바로가기 [Article Type] Clinical Trial
Plasma D-dimer value corrected by inflammatory markers in patients with SARS-CoV-2 infection: Its prognostic value in the diagnosis of venous thromboembolismSARS-CoV-2 감염 환자의 염증 표지자로 교정된 혈장 D-dimer 값: 정맥 혈전색전증 진단에 대한 예후적 가치Article Published on 2022-03-252022-09-11 Journal: Medicina clínica [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Acute-phase proteins age analyzed benefit best C-reactive protein case-control study Control COVID 19 COVID-19 cut-off cut-off point cutoff point D-dimer D-dimer level D-dimer levels D-dimer value detect determine diagnosed Diagnosis diagnostic diagnostic testing Diagnóstico dimer elevated English ferritin Ferritina FIBRIN fibrin fragment D fibrinogen Fragmento de fibrina D higher risk hospital Inflammatory marker inflammatory markers linear Linear model Linear regression media men Patient patients with SARS-CoV-2 plasma predicted Predictive Probability Prognostic value Proteínas de fase aguda ROC ROC Curve ROC curves screening method sensitivity Sex Spain Spanish specificity Thromboembolism Tromboembolismo venoso Usando Venous Thromboembolism venous thromboembolism. VTE [DOI] 10.1016/j.medcli.2021.03.034 PMC 바로가기 [Article Type] Article
Association between Coagulation Profile and Clinical Outcome in Children with SARS-CoV-2 Infection or MIS-C: A Multicenter Cross-Sectional StudyArticle Published on 2022-02-172022-10-31 Journal: Children [Category] COVID-19, [키워드] activated Admission affected age Blood children clinical clinical history Clinical outcome Coagulation collected COVID-19 cross-sectional D-dimer D-dimer value D-dimer values D-dimers diagnosed with COVID-19 Diagnosis died enrolled evaluate fibrinogen value higher risk increased risk Infection Inflammatory INR intensive care International IQR Limited management median age MIS-C multicenter multivariate logistic regression normalized outcome Patient pediatric performed Platelet predictor profile retrospective SARS-CoV-2 syndrome the patient the SARS-CoV-2 Univariate analysis [DOI] 10.3390/children9020279 PMC 바로가기 [Article Type] Article
Upper extremity deep vein thrombosis in COVID-19: Incidence and correlated risk factors in a cohort of non-ICU patientsResearch Article Published on 2022-01-122022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 95% CI adjusted affected age All the patient ARDS association Cohort complication of COVID-19 condition correlated COVID-19 infection COVID-19 patient CPAP cut off value D-dimer value Deep venous thrombosis Diagnosis DVT evaluate Evidence identify incidence Increased Infection International Local moderate-severe Mortality Multivariate analysis multivariate analysis non-ICU patient occur Occurrence paO2/fiO2 Patient patients performed pharmacological Pneumonia positive airway pressure Prevent Prophylaxis protocol provoking receiving recommendations Result Retrospective analysis risk factor significantly Thromboembolism Thromboprophylaxis thrombosis Univariate analysis Upper extremity upper limb venous Ventilation were used [DOI] 10.1371/journal.pone.0262522 PMC 바로가기 [Article Type] Research Article
Colchicine, COVID-19 and hematological parameters: A meta-analysis콜히친, COVID-19 및 혈액 학적 파라미터 : 메타 분석Meta-Analysis Published on 2021-12-012022-08-31 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, 바이오마커, [키워드] adjunct Anti-inflammatory anti-inflammatory properties Biomarker C-reactive protein C-reactive protein (CRP clinical and laboratory parameters ClinicalTrials Colchicine colchicine group colchicine. conducted COVID-19 COVID-19 infection COVID-19 patients COVID-19 treatment CRP D-dimer D-dimer value D-dimer values database databases determine Direct effect size Efficacy Elsevier Google Scholar hematological Inflammatory Inflammatory biomarker inflammatory biomarkers item Laboratory laboratory parameter Lactate lactate dehydrogenase LDH Meta-analysis moderate-to-severe COVID-19 patients morbidity and mortality Other Patient post treatment PRISMA Protein reducing reduction reductions in reported Reporting review SAGE SARS-CoV-2 Science Science Direct searched significant reductions SMD Treatment Trial trials Web of Science [DOI] 10.1002/jcla.24057 PMC 바로가기 [Article Type] Meta-Analysis
Targeting the Endothelium in the Treatment of COVID-19 Early Clinical Stages: Results of a Randomized Placebo-Controlled TrialConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 임상, [키워드] 95% CI 95% confidence interval analyzed Antithrombotic assigned benefit bleeding C reactive protein C-reactive protein calculated calculator Care caused clinical clinical disease Clinical stage Cluster Comorbidity Complication concerning conducted COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer D-dimer level D-dimer value determine difference Disease progression dose Effect Endothelial cell Endpoint evaluate the effect evaluated Fewer patient First wave Follow-up healthcare high risk hospital Hospital admission Inclusion inclusion criteria induce Intervention Kaplan-Meier curve limitation lockdown major bleeding medication Mortality normally distributed oral anticoagulant oxygen support participant Patient patients required hospitalization per-protocol analysis percentage performed physician Placebo pleiotropic Primary outcome progression randomized placebo-controlled trial Randomly receive reduced required responsible Result risk SARS-CoV-2 Serum level serum levels Seven Side effects significantly higher Standard of care student suggested sulodexide supplemental oxygen supplemental oxygen support synergistic t-test T-tests target targeting the placebo group Thromboembolic events treat analysis Treatment Trial Vascular Vascular endothelium was used were assessed were blinded Wilcoxon test [DOI] 10.1182/blood-2021-151814 [Article Type] Conference abstract
Feasibility and Clinical Outcomes of a Step Up Noninvasive Respiratory Support Strategy in Patients with Severe COVID-19 PneumoniaArticle Published on 2021-11-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Activation Acute respiratory failure appear asynchrony baseline bpm clinical conducted Continuous Positive Airway Pressure COVID-19 COVID-19 patients CPAP D-dimer value Desaturation deteriorate Endotracheal intubation enrolled feasible hemodynamic instability hospitals In-hospital in-hospital mortality Intubated intubation Italian LOS Lymphocyte count median Mortality multicenter NIV noninvasive respiratory Noninvasive ventilation outcome PaO Patient patients treated patients with COVID-19 Pneumonia positive airway pressure reduce respiratory respiratory distress respiratory rate retrospective secondary step Strategy treated Trial [DOI] 10.3390/jcm10225444 PMC 바로가기 [Article Type] Article
Coagulation profile and correlation between D-dimer, inflammatory markers, and COVID-19 severity in an Indonesian national referral hospital인도네시아 국립 위탁 병원에서 D-dimer, 염증 표지자 및 COVID-19 중증도 사이의 응고 프로파일 및 상관 관계Article Published on 2021-11-012022-09-11 Journal: The Journal of international medical research [Category] MERS, SARS, 바이오마커, [키워드] 95% confidence interval Accuracy acute respiratory distress acute respiratory distress syndrome Admission ARDS AUC C-reactive protein can be used characteristic Coagulopathy Combination Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 cases COVID-19 severity cross-sectional study CRP cutoff value D-dimer D-dimer value dimer disease evaluated ferritin Health Organization highest hospital Inflammation Inflammatory marker inflammatory markers marker median Mild moderate National on admission receiver receiver operating characteristic respiratory distress Respiratory distress syndrome Retrospective cross-sectional study severe ARDS severity Severity of infection Severity. syndrome WHO World Health Organization [DOI] 10.1177/03000605211059939 PMC 바로가기 [Article Type] Article